Premetastatic niche mechanics and organotropism in breast cancer

Journal article

Sarah Libring, Cynthia A. Reinhart-King
NPJ biological physics and mechanics, 2025

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Libring, S., & Reinhart-King, C. A. (2025). Premetastatic niche mechanics and organotropism in breast cancer. NPJ Biological Physics and Mechanics.

Chicago/Turabian Click to copy
Libring, Sarah, and Cynthia A. Reinhart-King. “Premetastatic Niche Mechanics and Organotropism in Breast Cancer.” NPJ biological physics and mechanics (2025).

MLA Click to copy
Libring, Sarah, and Cynthia A. Reinhart-King. “Premetastatic Niche Mechanics and Organotropism in Breast Cancer.” NPJ Biological Physics and Mechanics, 2025.

BibTeX Click to copy

@article{sarah2025a,
  title = {Premetastatic niche mechanics and organotropism in breast cancer},
  year = {2025},
  journal = {NPJ biological physics and mechanics},
  author = {Libring, Sarah and Reinhart-King, Cynthia A.}
}

Abstract

Numerous physical and mechanical changes occur in the premetastatic niche. Here, we review the mechanics of the premetastatic niche and how the altered extracellular matrix and cancer cell mechanics may play a role in organotropism in breast cancer. Future research into premetastatic niche development and organotropic cell behavior should address physical alterations and biomechanical effects to the same rigor that biochemical alterations are studied.